The Venoms registered a big win on Sunday at the MTN Omondi Stadium during a Premier League encounter.
Yunus Sentamu and Milton Karisa scored for Vipers while Dennis Iguma scored for KCCA FC.
Karim Watambala failed to beat KCCA’s Charles Lukwago in the 10th minute.
Vipers created a clear chance that should have resulted in a goal.
A combination between Herbert Achai and Julius Poloto almost broke the deadlock.
But Sadat Anaku’s shot from the final cross flew over the bar in the 20th minute.
A dangerous tackle on Achai saw Vipers’ Halid Lwaliwa become the first player to be yellow-carded in the 30th minute.
Richard Basangwa did well to lay the ball on Sentamu’s path.
But the forward could not make anything meaningful from the opportunity presented in the 40th minute.
Bobosi Byaruhanga then failed to open the scoring for Vipers in the 44th minute.
He found himself just in front of the goal but sent his effort wide.
Sentamu stunned the home side in the 50th minute with an opener before Karisa made it 2-0 two minutes later.
Iguma pulled one back for the Kasasiro Boys some five minutes later.
The Venoms remain second with 49 points while KCCA are fourth with 36 points.