Yunus Ssentamu’s brace and a goal each by Karim Watambala and David Bagoole gave the reigning champions the big win on a day.
Ssentamu could have scored the opener in the fifth minute but his header, from Orit’s delivery.
However, it landed in goalkeeper Andrew Ssekandi’s hands.
Ssentamu scored in the 21st minute from a spot-kick after he had been brought down in the penalty area.
Lawrence Tezikya could have doubled the lead in the 32nd minute but his shot went wide from a very good goal-scoring position.
Watambala scored the second goal after Orit laid a good pass in his way two minutes after Tezikya’s miss.
Bagoole scored the third for the rampant Venoms in the 47th minute, his first-ever for the champions.
Ssentamu scored his second in the 65th minute as he tapped a cross brought in by Paul Willa into the empty net.
Vipers is now second on the log with 46 points one point below table leaders URA FC.