Thursday will see two games played and the other two will be played on Friday after the completion of the last round of group matches on Monday evening.
The remaining eight teams are expected to provide top notch entertainment on the pitch over the two days.
AFCON U20 QF1: Cameroon vs Ghana, Stade Olympique, Thursday
This will be one of the ties to watch and what most people have referred to as the final before the final.
Cameroon finished top of Group A with a 100 percent record.
Meanwhile, Ghana who were in Group C managed a place in the last eight as one of the two best third placed teams.
They lost to Gambia in the last day of the group phase.
AFCON U20 QF2: Burkina Faso vs Uganda, Stade Cheikha Ould Boidiya, Thursday
The Burkinabes topped Group B with seven points after two wins and a draw.
They will come up against debutants Uganda who finished second in Group A.
Uganda won against Mozambique and hosts Mauritania, their only loss being against Cameroon.
AFCON U20 QF3: Morocco vs Tunisia, Stade Municipal de Nouadhibou, Friday
A North African derby all the way in Mauritania will see Group C table toppers Morocco face off with Tunisia.
Morocco finished off with seven points after wins over Tanzania and Gambia as well as a draw with Ghana.
They come up against one of the two best placed number threes in Tunisia who had four points.
They won over Namibia and a draw against Burkina Faso.
They lost to Central Africa Republic in the last round of group matches.
AFCON U20 QF4: Central Africa Republic vs Gambia, Stade Olympique, Friday
Both the Central Africa Republic (CAR) and Gambia managed to earn their automatic qualification slots on the final day of the group stage.
CAR shocked Tunisia in their last match to skip into second.
Meanwhile, Gambia were also winners on the last day beating Ghana 2-1 to edge them out of the automatic qualification slots.