Uganda Cranes will confirm their third consecutive qualification if they manage a win against South Sudan at Nyayo National Stadium.
When the two sides met on Thursday, Uganda won 1-0 to move to seven points from three games played. South Sudan on the other hand, are still on the bottom of Group B table without a point.
At Kamuzu Stadium, Group B table leaders Burkina Faso will visit Malawi with a win for The Stallions confirming a slot in the final tournament.
The Kamou Malo coached side is currently on seven points while Malawi are third on Group B table with three points from three games played.
When the two sides met on Thursday, Burkina Faso came out as victors with a 3-1 win.